Pharmacogenomics of the immunosuppressive agents

Pharmacological immunosuppressive agents.

A vast range of different compounds seem capable of depressing the immune response, however, it has been disappointing that so few of these have shown potential as immunosuppressive agents in man. The action of many has been to suppress lymphocyte reactivity in vitro and of those that are capable of prolonging graft survival in animals in addition, just a handful have been found to be safe and ...

[Immunosuppressive agents in Dermatology].

Immunosupressants are drugs that act in cell division and have anti-inflammatory effects. Therefore, they are essentially prescribed in the prevention of transplant rejection and in the treatment of autoimmune disorders and chronic inflammatory diseases, whose main example in Dermatology is psoriasis. In this work the most important immunosuppressive drugs and orientation to properly administer...

Differences among immunosuppressive agents.

Immunosuppressive agents have diverse (although often multiple) sites of action in the cell sequences that are involved in immune responses. New routes to selectivity are apparent at both the cellular and the biochemical level. Meanwhile, clinical work is finding new uses and more selective employment of the currently available agents.

Medicinal Plants as Immunosuppressive Agents in Traditional Iranian Medicine

Pharmacogenetics and pharmacogenomics of anticancer agents.

Large interindividual variation is observed in both the response and toxicity associated with anticancer therapy. The etiology of this variation is multifactorial, but is due in part to host genetic variations. Pharmacogenetic and pharmacogenomic studies have successfully identified genetic variants that contribute to this variation in susceptibility to chemotherapy. This review provides an ove...